AustralieFrV1, Main, Exploration, bibRecord, 002247

Changes in IgE sensitization and total IgE levels over 20 years of follow-up

Identifieur interne : 002247 ( Main/Exploration ); précédent : 002246; suivant : 002248

Changes in IgE sensitization and total IgE levels over 20 years of follow-up

Auteurs : André F. S. Amaral [Royaume-Uni] ; Roger B. Newson [Royaume-Uni] ; Michael J. Abramson [Australie] ; Josep M. Ant [Espagne] ; Roberto Bono [Italie] ; Angelo G. Corsico [Italie] ; Roberto De Marco [Italie] ; Pascal Demoly [France] ; Bertil Forsberg [Suède] ; Thorarinn Gislason [Islande] ; Joachim Heinrich [Allemagne] ; Ismael Huerta [Espagne] ; Christer Janson [Suède] ; Rain J Gi [Estonie] ; Jeong-Lim Kim [Suède] ; José Maldonado [Espagne] ; Jesús Martinez-Moratalla Rovira [Espagne] ; Catherine Neukirch [France] ; Dennis Nowak [Allemagne] ; Isabelle Pin [France] ; Nicole Probst-Hensch [Suisse] ; Chantal Raherison-Semjen [France] ; Cecilie Svanes [Norvège] ; Isabel Urrutia Landa [Espagne] ; Ronald Van Ree [Pays-Bas] ; Serge A. Versteeg [Pays-Bas] ; Joost Weyler [Belgique] ; Jan-Paul Zock [Espagne] ; Peter G. J. Burney [Royaume-Uni] ; Deborah L. Jarvis [Royaume-Uni]

Source :

The Journal of Allergy and Clinical Immunology [ 0091-6749 ] ; 2016.

RBID : PMC:4889785

Descripteurs français

KwdFr :
- Adulte, Allergènes (immunologie), Animaux, Chats, Europe, Exposition environnementale, Humains, Immunisation, Immunoglobuline E (immunologie), Immunoglobuline E (sang), Poaceae (immunologie), Pyroglyphidae (immunologie), Surveillance de la population, Études de suivi, Études séroépidémiologiques, Études transversales.
MESH :
- immunologie : Allergènes, Immunoglobuline E, Poaceae, Pyroglyphidae.
- sang : Immunoglobuline E.
- Adulte, Animaux, Chats, Europe, Exposition environnementale, Humains, Immunisation, Surveillance de la population, Études de suivi, Études séroépidémiologiques, Études transversales.

English descriptors

KwdEn :
- Adult, Allergens (immunology), Animals, Cats, Cross-Sectional Studies, Environmental Exposure, Europe, Follow-Up Studies, Humans, Immunization, Immunoglobulin E (blood), Immunoglobulin E (immunology), Poaceae (immunology), Population Surveillance, Pyroglyphidae (immunology), Seroepidemiologic Studies.
MESH :
- chemical , blood : Immunoglobulin E.
- chemical , immunology : Allergens, Immunoglobulin E.
- immunology : Poaceae, Pyroglyphidae.
- Adult, Animals, Cats, Cross-Sectional Studies, Environmental Exposure, Europe, Follow-Up Studies, Humans, Immunization, Population Surveillance, Seroepidemiologic Studies.

Abstract

Background

Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.

Objective

We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.

Methods

Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.

Results

Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.

Conclusion

Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889785

DOI: 10.1016/j.jaci.2015.09.037
PubMed: 26586040
PubMed Central: 4889785

Affiliations:

Le document en format XML

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<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
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<author><name sortKey="Maldonado, Jose" sort="Maldonado, Jose" uniqKey="Maldonado J" first="José" last="Maldonado">José Maldonado</name>
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<author><name sortKey="Nowak, Dennis" sort="Nowak, Dennis" uniqKey="Nowak D" first="Dennis" last="Nowak">Dennis Nowak</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich</wicri:regionArea>
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<author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<affiliation wicri:level="3"><nlm:aff id="aff26">Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble, France</nlm:aff>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff27">INSERM U823, Institut Albert Bonniot, Grenoble, France</nlm:aff>
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</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff28">Université Joseph Fourier, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name>
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<affiliation wicri:level="1"><nlm:aff id="aff30">University of Basel, Basel, Switzerland</nlm:aff>
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<author><name sortKey="Raherison Semjen, Chantal" sort="Raherison Semjen, Chantal" uniqKey="Raherison Semjen C" first="Chantal" last="Raherison-Semjen">Chantal Raherison-Semjen</name>
<affiliation wicri:level="3"><nlm:aff id="aff31">INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux, France</nlm:aff>
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<author><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name>
<affiliation wicri:level="1"><nlm:aff id="aff32">Centre for International Health, University of Bergen, Bergen, Norway</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="aff33">Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Occupational Medicine, Haukeland University Hospital, Bergen</wicri:regionArea>
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</author>
<author><name sortKey="Urrutia Landa, Isabel" sort="Urrutia Landa, Isabel" uniqKey="Urrutia Landa I" first="Isabel" last="Urrutia Landa">Isabel Urrutia Landa</name>
<affiliation wicri:level="1"><nlm:aff id="aff34">Department of Pneumology, Galdakao Hospital, Galdakao, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pneumology, Galdakao Hospital, Galdakao</wicri:regionArea>
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<author><name sortKey="Van Ree, Ronald" sort="Van Ree, Ronald" uniqKey="Van Ree R" first="Ronald" last="Van Ree">Ronald Van Ree</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea>
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<country xml:lang="fr">Belgique</country>
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<country xml:lang="fr">Espagne</country>
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<region nuts="2" type="region">Catalogne</region>
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<affiliation wicri:level="4"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
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<orgName type="university">Université Pompeu Fabra</orgName>
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<wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Changes in IgE sensitization and total IgE levels over 20 years of follow-up</title>
<author><name sortKey="Amaral, Andre F S" sort="Amaral, Andre F S" uniqKey="Amaral A" first="André F. S." last="Amaral">André F. S. Amaral</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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</affiliation>
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<author><name sortKey="Newson, Roger B" sort="Newson, Roger B" uniqKey="Newson R" first="Roger B." last="Newson">Roger B. Newson</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Primary Care and Public Health, School of Public Health, Imperial College, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Primary Care and Public Health, School of Public Health, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abramson, Michael J" sort="Abramson, Michael J" uniqKey="Abramson M" first="Michael J." last="Abramson">Michael J. Abramson</name>
<affiliation wicri:level="3"><nlm:aff id="aff3">School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Public Health & Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff5">IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>IMIM (Hospital del Mar Medical Research Institute), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université Pompeu Fabra</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7">CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bono, Roberto" sort="Bono, Roberto" uniqKey="Bono R" first="Roberto" last="Bono">Roberto Bono</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">Department of Public Health and Pediatrics, University of Turin, Turin, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Public Health and Pediatrics, University of Turin, Turin</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corsico, Angelo G" sort="Corsico, Angelo G" uniqKey="Corsico A" first="Angelo G." last="Corsico">Angelo G. Corsico</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation–University of Pavia, Pavia</wicri:regionArea>
<wicri:noRegion>Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Marco, Roberto" sort="De Marco, Roberto" uniqKey="De Marco R" first="Roberto" last="De Marco">Roberto De Marco</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona</wicri:regionArea>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pulmonology, Division of Allergy, Arnaud de Villeneuve Hospital, CHU Montpellier, and EPAR Team–UMR-S 1136 INSERM, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forsberg, Bertil" sort="Forsberg, Bertil" uniqKey="Forsberg B" first="Bertil" last="Forsberg">Bertil Forsberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff12">Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name>
<affiliation wicri:level="1"><nlm:aff id="aff13">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff14">Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Respiratory Medicine and Sleep, Landspitali–The National University Hospital of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology I, Helmholtz Zentrum, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff16">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huerta, Ismael" sort="Huerta, Ismael" uniqKey="Huerta I" first="Ismael" last="Huerta">Ismael Huerta</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Epidemiological Surveillance Section, Directorate General of Public Health, Department of Health of Asturias, Oviedo</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Janson, Christer" sort="Janson, Christer" uniqKey="Janson C" first="Christer" last="Janson">Christer Janson</name>
<affiliation wicri:level="4"><nlm:aff id="aff18">Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala</wicri:regionArea>
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<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="J Gi, Rain" sort="J Gi, Rain" uniqKey="J Gi R" first="Rain" last="J Gi">Rain J Gi</name>
<affiliation wicri:level="1"><nlm:aff id="aff19">Tartu University Hospital, Lung Clinic, Tartu, Estonia</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>Tartu University Hospital, Lung Clinic, Tartu</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Kim, Jeong Lim" sort="Kim, Jeong Lim" uniqKey="Kim J" first="Jeong-Lim" last="Kim">Jeong-Lim Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Publich Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maldonado, Jose" sort="Maldonado, Jose" uniqKey="Maldonado J" first="José" last="Maldonado">José Maldonado</name>
<affiliation wicri:level="1"><nlm:aff id="aff21">Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unit of Clinical Management of Pneumology and Allergy, University Hospital of Huelva, Huelva</wicri:regionArea>
<wicri:noRegion>Huelva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinez Moratalla Rovira, Jesus" sort="Martinez Moratalla Rovira, Jesus" uniqKey="Martinez Moratalla Rovira J" first="Jesús" last="Martinez-Moratalla Rovira">Jesús Martinez-Moratalla Rovira</name>
<affiliation wicri:level="1"><nlm:aff id="aff22">Unit of Pneumology, University Hospital of Albacete, Albacete, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unit of Pneumology, University Hospital of Albacete, Albacete</wicri:regionArea>
<wicri:noRegion>Albacete</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neukirch, Catherine" sort="Neukirch, Catherine" uniqKey="Neukirch C" first="Catherine" last="Neukirch">Catherine Neukirch</name>
<affiliation wicri:level="3"><nlm:aff id="aff23">INSERM UMR1152, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR1152, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff24">Université Paris Diderot Paris 7, UMR1152, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris Diderot Paris 7, UMR1152, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris Diderot-Paris 7</orgName>
</affiliation>
</author>
<author><name sortKey="Nowak, Dennis" sort="Nowak, Dennis" uniqKey="Nowak D" first="Dennis" last="Nowak">Dennis Nowak</name>
<affiliation wicri:level="3"><nlm:aff id="aff25">Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig-Maximilians-Universität of Munich, and the German Center for Lung Research, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
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<wicri:regionArea>Pédiatrie, Pole Couple Enfants, CHU de Grenoble, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
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<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff27">INSERM U823, Institut Albert Bonniot, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
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<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff28">Université Joseph Fourier, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Joseph Fourier, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
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<settlement type="city">Grenoble</settlement>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name>
<affiliation wicri:level="1"><nlm:aff id="aff29">Swiss Tropical and Public Health Institute, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff30">University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Raherison Semjen, Chantal" sort="Raherison Semjen, Chantal" uniqKey="Raherison Semjen C" first="Chantal" last="Raherison-Semjen">Chantal Raherison-Semjen</name>
<affiliation wicri:level="3"><nlm:aff id="aff31">INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U897, Institute of Public health and Epidemiology, Bordeaux University, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name>
<affiliation wicri:level="1"><nlm:aff id="aff32">Centre for International Health, University of Bergen, Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Centre for International Health, University of Bergen, Bergen</wicri:regionArea>
<wicri:noRegion>Bergen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff33">Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Occupational Medicine, Haukeland University Hospital, Bergen</wicri:regionArea>
<wicri:noRegion>Bergen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Urrutia Landa, Isabel" sort="Urrutia Landa, Isabel" uniqKey="Urrutia Landa I" first="Isabel" last="Urrutia Landa">Isabel Urrutia Landa</name>
<affiliation wicri:level="1"><nlm:aff id="aff34">Department of Pneumology, Galdakao Hospital, Galdakao, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pneumology, Galdakao Hospital, Galdakao</wicri:regionArea>
<wicri:noRegion>Galdakao</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Ree, Ronald" sort="Van Ree, Ronald" uniqKey="Van Ree R" first="Ronald" last="Van Ree">Ronald Van Ree</name>
<affiliation wicri:level="4"><nlm:aff id="aff35">Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Versteeg, Serge A" sort="Versteeg, Serge A" uniqKey="Versteeg S" first="Serge A." last="Versteeg">Serge A. Versteeg</name>
<affiliation wicri:level="4"><nlm:aff id="aff36">Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Weyler, Joost" sort="Weyler, Joost" uniqKey="Weyler J" first="Joost" last="Weyler">Joost Weyler</name>
<affiliation wicri:level="4"><nlm:aff id="aff37">Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Epidemiology and Social Medicine and the StatUA Statistics Centre, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff6">Universitat Pompeu Fabra (UPF), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universitat Pompeu Fabra (UPF), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université Pompeu Fabra</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7">CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burney, Peter G J" sort="Burney, Peter G J" uniqKey="Burney P" first="Peter G. J." last="Burney">Peter G. J. Burney</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jarvis, Deborah L" sort="Jarvis, Deborah L" uniqKey="Jarvis D" first="Deborah L." last="Jarvis">Deborah L. Jarvis</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Allergy and Clinical Immunology</title>
<idno type="ISSN">0091-6749</idno>
<idno type="eISSN">1097-6825</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Allergens (immunology)</term>
<term>Animals</term>
<term>Cats</term>
<term>Cross-Sectional Studies</term>
<term>Environmental Exposure</term>
<term>Europe</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunization</term>
<term>Immunoglobulin E (blood)</term>
<term>Immunoglobulin E (immunology)</term>
<term>Poaceae (immunology)</term>
<term>Population Surveillance</term>
<term>Pyroglyphidae (immunology)</term>
<term>Seroepidemiologic Studies</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Allergènes (immunologie)</term>
<term>Animaux</term>
<term>Chats</term>
<term>Europe</term>
<term>Exposition environnementale</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Immunoglobuline E (immunologie)</term>
<term>Immunoglobuline E (sang)</term>
<term>Poaceae (immunologie)</term>
<term>Pyroglyphidae (immunologie)</term>
<term>Surveillance de la population</term>
<term>Études de suivi</term>
<term>Études séroépidémiologiques</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Allergens</term>
<term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Allergènes</term>
<term>Immunoglobuline E</term>
<term>Poaceae</term>
<term>Pyroglyphidae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Poaceae</term>
<term>Pyroglyphidae</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline E</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Cats</term>
<term>Cross-Sectional Studies</term>
<term>Environmental Exposure</term>
<term>Europe</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunization</term>
<term>Population Surveillance</term>
<term>Seroepidemiologic Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Chats</term>
<term>Europe</term>
<term>Exposition environnementale</term>
<term>Humains</term>
<term>Immunisation</term>
<term>Surveillance de la population</term>
<term>Études de suivi</term>
<term>Études séroépidémiologiques</term>
<term>Études transversales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.</p>
</sec>
<sec><title>Objective</title>
<p>We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.</p>
</sec>
<sec><title>Methods</title>
<p>Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.</p>
</sec>
<sec><title>Results</title>
<p>Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.</p>
</sec>
<sec><title>Conclusion</title>
<p>Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.</p>
</sec>
</div>
</front>
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<author><name sortKey="Jabara, H H" uniqKey="Jabara H">H.H. Jabara</name>
</author>
<author><name sortKey="Brodeur, S R" uniqKey="Brodeur S">S.R. Brodeur</name>
</author>
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<author><name sortKey="Sempowski, G D" uniqKey="Sempowski G">G.D. Sempowski</name>
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<author><name sortKey="Wells, A F" uniqKey="Wells A">A.F. Wells</name>
</author>
<author><name sortKey="Hale, L P" uniqKey="Hale L">L.P. Hale</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Yagi, T" uniqKey="Yagi T">T. Yagi</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Fujiwara, M" uniqKey="Fujiwara M">M. Fujiwara</name>
</author>
<author><name sortKey="Kishimoto, S" uniqKey="Kishimoto S">S. Kishimoto</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Strachan, D P" uniqKey="Strachan D">D.P. Strachan</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Svanes, C" uniqKey="Svanes C">C. Svanes</name>
</author>
<author><name sortKey="Jarvis, D" uniqKey="Jarvis D">D. Jarvis</name>
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</author>
<author><name sortKey="Burney, P" uniqKey="Burney P">P. Burney</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Ziello, C" uniqKey="Ziello C">C. Ziello</name>
</author>
<author><name sortKey="Sparks, T H" uniqKey="Sparks T">T.H. Sparks</name>
</author>
<author><name sortKey="Estrella, N" uniqKey="Estrella N">N. Estrella</name>
</author>
<author><name sortKey="Belmonte, J" uniqKey="Belmonte J">J. Belmonte</name>
</author>
<author><name sortKey="Bergmann, K C" uniqKey="Bergmann K">K.C. Bergmann</name>
</author>
<author><name sortKey="Bucher, E" uniqKey="Bucher E">E. Bucher</name>
</author>
</analytic>
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</author>
<author><name sortKey="Jager, S" uniqKey="Jager S">S. Jager</name>
</author>
<author><name sortKey="Berger, U" uniqKey="Berger U">U. Berger</name>
</author>
<author><name sortKey="Sikoparija, B" uniqKey="Sikoparija B">B. Sikoparija</name>
</author>
<author><name sortKey="Hallsdottir, M" uniqKey="Hallsdottir M">M. Hallsdottir</name>
</author>
<author><name sortKey="Sauliene, I" uniqKey="Sauliene I">I. Sauliene</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Amato, G" uniqKey="D Amato G">G. D'Amato</name>
</author>
<author><name sortKey="Cecchi, L" uniqKey="Cecchi L">L. Cecchi</name>
</author>
<author><name sortKey="Bonini, S" uniqKey="Bonini S">S. Bonini</name>
</author>
<author><name sortKey="Nunes, C" uniqKey="Nunes C">C. Nunes</name>
</author>
<author><name sortKey="Annesi Maesano, I" uniqKey="Annesi Maesano I">I. Annesi-Maesano</name>
</author>
<author><name sortKey="Behrendt, H" uniqKey="Behrendt H">H. Behrendt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ackaert, C" uniqKey="Ackaert C">C. Ackaert</name>
</author>
<author><name sortKey="Kofler, S" uniqKey="Kofler S">S. Kofler</name>
</author>
<author><name sortKey="Horejs Hoeck, J" uniqKey="Horejs Hoeck J">J. Horejs-Hoeck</name>
</author>
<author><name sortKey="Zulehner, N" uniqKey="Zulehner N">N. Zulehner</name>
</author>
<author><name sortKey="Asam, C" uniqKey="Asam C">C. Asam</name>
</author>
<author><name sortKey="Von Grafenstein, S" uniqKey="Von Grafenstein S">S. von Grafenstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albertine, J M" uniqKey="Albertine J">J.M. Albertine</name>
</author>
<author><name sortKey="Manning, W J" uniqKey="Manning W">W.J. Manning</name>
</author>
<author><name sortKey="Dacosta, M" uniqKey="Dacosta M">M. DaCosta</name>
</author>
<author><name sortKey="Stinson, K A" uniqKey="Stinson K">K.A. Stinson</name>
</author>
<author><name sortKey="Muilenberg, M L" uniqKey="Muilenberg M">M.L. Muilenberg</name>
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<author><name sortKey="Rogers, C A" uniqKey="Rogers C">C.A. Rogers</name>
</author>
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<author><name sortKey="Janssens Maenhout, G" uniqKey="Janssens Maenhout G">G. Janssens-Maenhout</name>
</author>
<author><name sortKey="Muntean, M" uniqKey="Muntean M">M. Muntean</name>
</author>
<author><name sortKey="Peters, J A H W" uniqKey="Peters J">J.A.H.W. Peters</name>
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</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Espagne</li>
<li>Estonie</li>
<li>France</li>
<li>Islande</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bavière</li>
<li>Catalogne</li>
<li>Communauté de Madrid</li>
<li>District de Haute-Bavière</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Nouvelle-Aquitaine</li>
<li>Piémont</li>
<li>Province d'Anvers</li>
<li>Rhône-Alpes</li>
<li>Région flamande</li>
<li>Svealand</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Anvers</li>
<li>Barcelone</li>
<li>Bordeaux</li>
<li>Grenoble</li>
<li>Londres</li>
<li>Madrid</li>
<li>Melbourne</li>
<li>Munich</li>
<li>Paris</li>
<li>Turin</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université Joseph Fourier</li>
<li>Université Paris Diderot-Paris 7</li>
<li>Université Pompeu Fabra</li>
<li>Université d'Amsterdam</li>
<li>Université d'Anvers</li>
<li>Université d'Uppsala</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Amaral, Andre F S" sort="Amaral, Andre F S" uniqKey="Amaral A" first="André F. S." last="Amaral">André F. S. Amaral</name>
</region>
<name sortKey="Burney, Peter G J" sort="Burney, Peter G J" uniqKey="Burney P" first="Peter G. J." last="Burney">Peter G. J. Burney</name>
<name sortKey="Jarvis, Deborah L" sort="Jarvis, Deborah L" uniqKey="Jarvis D" first="Deborah L." last="Jarvis">Deborah L. Jarvis</name>
<name sortKey="Newson, Roger B" sort="Newson, Roger B" uniqKey="Newson R" first="Roger B." last="Newson">Roger B. Newson</name>
<name sortKey="Newson, Roger B" sort="Newson, Roger B" uniqKey="Newson R" first="Roger B." last="Newson">Roger B. Newson</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Abramson, Michael J" sort="Abramson, Michael J" uniqKey="Abramson M" first="Michael J." last="Abramson">Michael J. Abramson</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name>
</region>
<name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name>
<name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name>
<name sortKey="Ant, Josep M" sort="Ant, Josep M" uniqKey="Ant J" first="Josep M." last="Ant">Josep M. Ant</name>
<name sortKey="Huerta, Ismael" sort="Huerta, Ismael" uniqKey="Huerta I" first="Ismael" last="Huerta">Ismael Huerta</name>
<name sortKey="Maldonado, Jose" sort="Maldonado, Jose" uniqKey="Maldonado J" first="José" last="Maldonado">José Maldonado</name>
<name sortKey="Martinez Moratalla Rovira, Jesus" sort="Martinez Moratalla Rovira, Jesus" uniqKey="Martinez Moratalla Rovira J" first="Jesús" last="Martinez-Moratalla Rovira">Jesús Martinez-Moratalla Rovira</name>
<name sortKey="Urrutia Landa, Isabel" sort="Urrutia Landa, Isabel" uniqKey="Urrutia Landa I" first="Isabel" last="Urrutia Landa">Isabel Urrutia Landa</name>
<name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name>
<name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name>
<name sortKey="Zock, Jan Paul" sort="Zock, Jan Paul" uniqKey="Zock J" first="Jan-Paul" last="Zock">Jan-Paul Zock</name>
</country>
<country name="Italie"><region name="Piémont"><name sortKey="Bono, Roberto" sort="Bono, Roberto" uniqKey="Bono R" first="Roberto" last="Bono">Roberto Bono</name>
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<name sortKey="Corsico, Angelo G" sort="Corsico, Angelo G" uniqKey="Corsico A" first="Angelo G." last="Corsico">Angelo G. Corsico</name>
<name sortKey="De Marco, Roberto" sort="De Marco, Roberto" uniqKey="De Marco R" first="Roberto" last="De Marco">Roberto De Marco</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Demoly, Pascal" sort="Demoly, Pascal" uniqKey="Demoly P" first="Pascal" last="Demoly">Pascal Demoly</name>
</region>
<name sortKey="Neukirch, Catherine" sort="Neukirch, Catherine" uniqKey="Neukirch C" first="Catherine" last="Neukirch">Catherine Neukirch</name>
<name sortKey="Neukirch, Catherine" sort="Neukirch, Catherine" uniqKey="Neukirch C" first="Catherine" last="Neukirch">Catherine Neukirch</name>
<name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<name sortKey="Raherison Semjen, Chantal" sort="Raherison Semjen, Chantal" uniqKey="Raherison Semjen C" first="Chantal" last="Raherison-Semjen">Chantal Raherison-Semjen</name>
</country>
<country name="Suède"><noRegion><name sortKey="Forsberg, Bertil" sort="Forsberg, Bertil" uniqKey="Forsberg B" first="Bertil" last="Forsberg">Bertil Forsberg</name>
</noRegion>
<name sortKey="Janson, Christer" sort="Janson, Christer" uniqKey="Janson C" first="Christer" last="Janson">Christer Janson</name>
<name sortKey="Kim, Jeong Lim" sort="Kim, Jeong Lim" uniqKey="Kim J" first="Jeong-Lim" last="Kim">Jeong-Lim Kim</name>
</country>
<country name="Islande"><noRegion><name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name>
</noRegion>
<name sortKey="Gislason, Thorarinn" sort="Gislason, Thorarinn" uniqKey="Gislason T" first="Thorarinn" last="Gislason">Thorarinn Gislason</name>
</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
</region>
<name sortKey="Heinrich, Joachim" sort="Heinrich, Joachim" uniqKey="Heinrich J" first="Joachim" last="Heinrich">Joachim Heinrich</name>
<name sortKey="Nowak, Dennis" sort="Nowak, Dennis" uniqKey="Nowak D" first="Dennis" last="Nowak">Dennis Nowak</name>
</country>
<country name="Estonie"><noRegion><name sortKey="J Gi, Rain" sort="J Gi, Rain" uniqKey="J Gi R" first="Rain" last="J Gi">Rain J Gi</name>
</noRegion>
</country>
<country name="Suisse"><noRegion><name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name>
</noRegion>
<name sortKey="Probst Hensch, Nicole" sort="Probst Hensch, Nicole" uniqKey="Probst Hensch N" first="Nicole" last="Probst-Hensch">Nicole Probst-Hensch</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name>
</noRegion>
<name sortKey="Svanes, Cecilie" sort="Svanes, Cecilie" uniqKey="Svanes C" first="Cecilie" last="Svanes">Cecilie Svanes</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Ree, Ronald" sort="Van Ree, Ronald" uniqKey="Van Ree R" first="Ronald" last="Van Ree">Ronald Van Ree</name>
</region>
<name sortKey="Versteeg, Serge A" sort="Versteeg, Serge A" uniqKey="Versteeg S" first="Serge A." last="Versteeg">Serge A. Versteeg</name>
</country>
<country name="Belgique"><region name="Région flamande"><name sortKey="Weyler, Joost" sort="Weyler, Joost" uniqKey="Weyler J" first="Joost" last="Weyler">Joost Weyler</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Changes in IgE sensitization and total IgE levels over 20 years of follow-up

Changes in IgE sensitization and total IgE levels over 20 years of follow-up

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	Serveur d'exploration sur les relations entre la France et l'Australie
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